منابع مشابه
Telomerase, senescence and ageing.
Telomeres serve to camouflage chromosome ends from the DNA damage response machinery. Telomerase activity is required to maintain telomeres. One consequence of telomere dysfunction is cellular senescence, a permanent growth arrest state. We review the key regulators of cellular senescence and recent in vivo evidence which supports p53-dependent senescence induced by short telomeres as a potent ...
متن کاملPredatory senescence in ageing wolves.
It is well established that ageing handicaps the ability of prey to escape predators, yet surprisingly little is known about how ageing affects the ability of predators to catch prey. Research into long-lived predators has assumed that adults have uniform impacts on prey regardless of age. Here we use longitudinal data from repeated observations of individually-known wolves (Canis lupus) huntin...
متن کاملAgeing and immunity: addressing immune senescence to ensure healthy ageing.
Among the greatest achievements of the 20th century, prolongation of life expectancy has been the result of improved health conditions, decreased childhood mortality, lower incidence of infectious diseases. The consequence is the rapid ageing of the world population, with the elderly representing over 25% of the entire population by the year 2030, of which 75% living in less developed countries...
متن کاملStress, cell senescence and organismal ageing
Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key mechanism driving replicative senescence in human fibroblasts. Later, pioneering work by Olivier Toussaint and others showed that stress plays a major role in the induction of senescence in vitro, a phenomenon known as ...
متن کاملSenescence and food limitation in a slowly ageing spider
1. Evidence for reproductive senescence in invertebrate natural populations is scant probably because most groups are short-lived or because they lack natural markers of age. 2. Lycosa tarantula (L.) (the Mediterranean Tarantula) (Araneae, Lycosidae) is a slowly ageing burrowing wolf spider, in which females can reproduce for two consecutive seasons. Females in their first reproductive season (...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology
سال: 2011
ISSN: 0019-5154
DOI: 10.4103/0019-5154.91816